腎クリアランスに及ぼす運動強度の影響

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  • EFFECTS OF EXERCISE INTENSITY ON RENAL CLEARANCE PARAMETERS
  • ジン クリアランス ニ オヨボス ウンドウ キョウド ノ エイキョウ

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A study was designed to examine the effects of exercise intensity on renal clearance parameters. Five healthy male subjects underwent exercise tests on an bicycle ergometer at 4 different work loads for 15 min. The indicators of exercise intensity employed were the percentage of maximal oxygen uptake (%VO2max), heart rate (HR) and blood lactate level (La) . As parameters of renal clearance, para-aminohippurate clearance (CPAH), thiosulfate clearance (Cthio) and creatinine clearance (Ccr) were measured by the continuous infusion technique during the exercise.<BR>1) The renal clearance parameters during exercise decreased linearly as the exercise intensity increased. The percentage of maximal oxygen uptake at the onset of the decreases in %CPAH, %Cchiu and %Ccr were 36, 45 and 47%VO2max, respectively.<BR>2) Among the indicators of exercise intensity, the decrease in La showed the closest correlation with renal clearance during the exercise.<BR>3) The renal plasma flow, which was measured as CPAH, began to decrease linearly at a significantly lower exercise intensity than the glomerular filtration rate, which was measured as both Cthio and Ccr.<BR>The above results suggest that renal clearance parameters begin to decrease at the threshold as exercise intensity increases.

収録刊行物

  • 体力科学

    体力科学 41 (2), 147-155, 1992

    一般社団法人日本体力医学会

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