小児膵癌に関する臨床的並びに病理学的検討 : 7才児に発生した膵癌の1例をもとに

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  • The Clinical and Pathological Study on Pancreatic Carcinoma in Childhood : An Analysis of a Case of 7-year-old Patient

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A case of pancreatic carcinoma in a 7-year-old female is presented. The clinical and histopathological features are discussed as follow. There are no "squamoid" patterns in the histology ot this tumor. The immunohistochemistry showed that the tumor cells were positive for alpha-fetoprotein (AFP) and pancreatin amylase, and negative for carcino-embryonic anti-gen, somatostatin, insulin and glucagon. The above mentioned characteristic of this tumor strongly suggest acinus origin, rather than "pancreaticoblastoma" group which has been reported by Horie, et al. The serum AFP level was high and well correrated with the change of the tumor size. We could not find any case reports of such a AFP producing pancreatic carcinoma of acinus origin in adults. This fact many suggest that there are biological difference between the pancreatic acinar cell carcinoma in adults and children. It seems helpful to apply the recently available tumor markers such as pancreatin amylase and pancreatico oncofetal antigen (POA) for the elucidation of the histogenesis of this type of tumors. We treated this patient with combination chemotherapy of VAC, CDDP, and FT, resulting in only transient antitumor effects.

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