正期産児・流早産児の抗体産生低下機序についての検討  [in Japanese] A Study of Underlying Immunoglobulin Production by Neonates  [in Japanese]

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Abstract

胎生期には児の抗体産生能が不良であるが, 本機序を解析した. 1. 正期産児単核球をStaphylococcus aureus Cowan I菌体成分(SAC)刺激した際, IgG, IgM産生量とも極めて不良であったが, 成人単核球PWM刺激上清を10%量添加することにより, 抗体産生量は著明に増加した. 2. 正期産児抗体産生を誘導する因子は成人T細胞培養上清中に存在した. 3. B cell differentiation factorγ(BCDFγ), BCDFμ産生量はともに正期産児・早期産児で成人に比し有意に(p<0.00005)低下していた. 4.33週未満の早期産児単核球をSAC刺激した際, 成人単核球PWM刺激上清を加えてもIgM, IgG産生は不良であり, とくにIgG産生亢進はほとんど認められなかった. 以上より, 33週以降の児においては抗体産生不良はT細胞より産生されるBCDFの低下に起因し, 33週未満の児ではそれに加えてB細胞側の未熟性もその成因であった.

During the prenatal period the ability of the fetus mononuclear cells (MNC) to produce antibodies is impaired. 1. In term infants, IgG production with only Staphylococcus aureus Cowan I strain (SAC) stimulation was significantly decreased (p<0.00005) as compared with adults. However, when adult MNC supernatant stimulated with Pokeweed mitogen (PWM-sup) was given to full term infants, antibody production significantly increased. 2. The activity inducing antibody production in the full term infant MNC is present primarily in the adult T cell culture supernatant. 3. B cell differentiation factory (BCDFγ) and BCDFμ, which induce IgG and IgM production, respectively, were significantly reduced in premature and full term infants (p<0.00005) as compared with adult. 4. By giving adult PWM-sup to the under 33-week-old infants MNC with SAC stimulation, the induction of both IgG and IgM was reduced, and IgG production was especially inadequate. From the above, it is thought that in full term infants, the production of BCDFγ and BCDFμ which are produced by T cells is reduced compared to that of adults, and that this is mainly responsible for the reduced antibody production. In addition, in the under 33-week-old infants, the immaturity of B cells and inadequate BCDF production induce underlying poor or inadequate immunoglobulin production.

Journal

  • 日本産科婦人科學會雜誌

    日本産科婦人科學會雜誌 43(5), 516-522, 1991

    日本産科婦人科学会

Cited by:  2

Codes

  • NII Article ID (NAID)
    110002106079
  • NII NACSIS-CAT ID (NCID)
    AN00190060
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • Data Source
    CJPref  NII-ELS  NDL-Digital 
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