The Role of Vitamin E during Pregnancy : Anti Platelet Aggregation Activity of α-Tocopherol

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  • 妊娠時におけるビタミンEの役割 : 血小板凝集阻止活性を中心に

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Abstract

To clarify the role of vitamin E(α-tocopherol) during pregnancy, we mainly investigated the relation between platelet function and vitamin E and obtained the following results. 1. The concentration of vitamin E(α-tocopherol) in plasma and platelet increased gradually during pregnancy. The concentration of vitamin E in plasma was 6.65μg/ml in non pregnant women and 15.5μg/ml in full term pregnant women. And the concentration of vitamin E in platelet was 99μg/g protein in non pregnant women and 244μg/g protein in full term pregnant women. 2. Vitamin E(α-tocopherol) inhibited platelet aggregation induced by ADP(adenosine diphosphate) and PAF(platelet activating factor). At a concentration of 500μg/ml vitamin E almost combletely inhibited platelet aggregation induced by ADP and PAF. 3. There exists a strong platelet aggregation inhibiting activity in human placental brush border membrane vesicles. At a protein concentration of 20μg/ml the brush border membrane vesicles almost completely inhibited platelet aggregation induced by ADP and PAF. 4. With the co-existence of the brush border membrane vesicles, the platelet aggregation inhibiting activity of vitamin E(α-tocopherol) increased prominently. These results indicate that vitamin E plays an important role in the regulation of platelet function and might contribute to the maintenance of placental microcirculation by inhibiting platetelet aggregation.

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