卵巣癌初期治療終了時におけるCA125値と予後  [in Japanese] The Prognosis of Ovarian Cancer Depends on the CA125 Value at the End of Induction Therapy  [in Japanese]

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Author(s)

    • 三輪 勝洋 MIWA Katsuhiro
    • 鹿児島大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Faculty of Medicine Kagoshima University
    • 堂園 晴彦 DOZONO Haruhiko
    • 鹿児島大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Faculty of Medicine Kagoshima University
    • 新村 亮二 SHINMURA Ryouji
    • 鹿児島大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Faculty of Medicine Kagoshima University
    • 松元 保 MATSUMOTO Tamotsu
    • 鹿児島大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Faculty of Medicine Kagoshima University
    • 池田 俊一 IKEDA Shunichi
    • 鹿児島大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Faculty of Medicine Kagoshima University
    • 永田 行博 NAGATA Yukihiro
    • 鹿児島大学医学部産科婦人科学教室 Department of Obstetrics and Gynecology, Faculty of Medicine Kagoshima University

Abstract

卵巣癌初期治療終了時におけるCA125値と予後の相関を検討した. 対象は卵巣癌Stage III 15例, Stage IV 1例であった. 初期治療(初回手術+化学療法3コース)終了時のCA125値が35units/ml以下に下降した群は, 初回手術後18カ月から45カ月たった現在も全例生存中である. しかし35units/ml以下に下降しなかった群は, 初回手術後16カ月以内に全例死亡した. そして統計学的に両群の生存率には有意な差を認めた. 以上の結果より, 卵巣癌の予後に影響を与える最も重要な因子は初期治療終了時におけるCA125の正常化であることが判明した.

The prognosis of ovarian cancer depends on the CA125 value at the end of induction therapy. The relationship between the prognosis and the CA125 value at the end of induction therapy was analysed in 16 ovarian cancers. In the group with a CA125 value less than 35 units/ml after the induction therapy (initial surgery + 3 courses of chemotherapy) all patients have survived for 18~45 months since the initial treatment to the present, whereas in the group with a CA125 value above 35 units/ml all patients died within 16 months after the initial treatment. Comparison of the survival rates in these two groups showed a significant difference. These results suggest that the most important factor that affects prognosis in patients with ovarian cancer is the normalization of the CA125 value after the induction therapy.

Journal

  • 日本産科婦人科學會雜誌

    日本産科婦人科學會雜誌 43(5), 557-561, 1991

    日本産科婦人科学会

Codes

  • NII Article ID (NAID)
    110002106092
  • NII NACSIS-CAT ID (NCID)
    AN00190060
  • Text Lang
    JPN
  • Data Source
    NII-ELS  NDL-Digital 
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