Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue

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  • Kajimoto Kazuaki
    Institute for Genome Research
  • Yamazaki Naoshi
    Faculty of Pharmaceutical Sciences, The University of Tokushima
  • Kataoka Masatoshi
    Institute for Genome Research
  • Terada Hiroshi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Shinohara Yasuo
    Institute for Genome Research Faculty of Pharmaceutical Sciences, The University of Tokushima Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)

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Abstract

Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT.

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