Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages

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Author(s)

    • Manabe Kazuyoshi
    • 徳島大学医学部 Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Sone Saburo
    • 徳島大学医学部 Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Nishioka Yasuhiko
    • 徳島大学医学部 Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Kishi Jun
    • Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Inayama Mami
    • Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Aono Yoshinori
    • Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School
    • Nakamura Yoichi
    • Clinical Research Center for Allergy and Rheumatology, National Kochi Hospital
    • Ogushi Fumitaka
    • Clinical Research Center for Allergy and Rheumatology, National Kochi Hospital
    • Bando Hiroyasu
    • Department of Pulmonary Medicine, Tokushima Prefectural Central Hospital
    • Tani Kenji
    • Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School

Abstract

Macrophage-derived chemokine (MDC/CCL22) and thymus-and activation-regulated chemokine (TARC/CCL17) are ligands for CC chemokine receptor 4. Recently, TARC has been reported to play a role in the pathogenesis of idiopathic eosinophilic pneumonia (IEP). The purpose of this study was to evaluate the role of MDC in IEP and other interstitial lung diseases (ILDs). MDC and TARC in the bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay in patients with ILDs and healthy volunteers (HV). We also examined the expression of MDC mRNA in alveolar macrophages (AM) by real-time quantitative reverse transcriptase-polymerase chain reaction. Both MDC and TARC were detected only in BALF obtained from IEP patients. The concentration of MDC was higher than that of TARC in all cases. The level of MDC in IEP correlated with that of TARC. AM from IEP patients expressed a significantly higher amount of MDC than that from HV at the levels of protein and mRNA. MDC in BALF from IEP dramatically decreased when patients achieved remission. These findings suggest that MDC, in addition to TARC, might be involved in the pathogenesis of IEP, and AM play a role in the elevation of MDC in IEP. J. Med. Invest. 52: 85-92, February, 2005

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 52(1-2), 85-92, 2005

    The University of Tokushima

Cited by:  1

Codes

  • NII Article ID (NAID)
    110002261665
  • NII NACSIS-CAT ID (NCID)
    AA11166929
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    1343-1420
  • Data Source
    CJPref  NII-ELS  IR  J-STAGE 
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