Glioblastoma Multiforme in the Left Frontal Lobe Subsequent to Malignant Lymphoma in the Right Orbit-Case Report-

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Author(s)

    • MURAKI Masaaki
    • 新城市民病院脳神経外科 Department of Neurosurgery, Shinshiro City Hospital
    • HIRAMATSU Hisaya
    • 新城市民病院脳神経外科 Department of Neurosurgery, Shinshiro City Hospital
    • TSUKAMOTO Katsuyuki
    • 新城市民病院脳神経外科 Department of Neurosurgery, Shinshiro City Hospital
    • HINOKUMA Kaoru
    • Department of Neurosurgery, Hamamatsu University School of Medicine
    • UEMURA Kenichi
    • Department of Neurosurgery, Hamamatsu University School of Medicine
    • MASAGO Atsuo
    • Department of Neurosurgery, Nagoya City University Medical School
    • UEDA Yukihiko
    • Department of Neurosurgery, Nagoya City University Medical School
    • MABE Hideo
    • Department of Neurosurgery, Nagoya City University Medical School
    • KURODA Makoto
    • Department of Pathology, Fujita Health University School of Medicine

Abstract

右眼窩内悪性リンパ腫に左前頭葉神経膠芽腫が続発した重複悪性腫瘍の1例を経験した。症例は62才男性。右眼球突出を主訴に来院し、MRIで右眼窩内上外側に均一に造影される病変を認めた。開頭摘出され、組織は非ホジキンリンパ腫で引き続き30Gyの放射線治療が施行された。11ヶ月後のMRIで左前頭葉実質内に点状に造影される病変を認めた。その約2ヶ月後より行動異常、失語があり、MRIで左前頭葉にリング状に造影される病変を認めた。開頭全摘出され組織は神経膠芽腫であった。重複悪性腫瘍は増加の傾向にあり、悪性腫瘍治療後も他の悪性腫瘍の発生に注意する必要があると思われた。また神経膠芽腫の早期像をとらえる点で造影MRIは極めて有用と思われた。

A 62-year-old male presented with glioblastoma multiforme in the left frontal lobe manifesting as motor aphasia, subsequent to a malignant lymphoma in the right orbit. He underwent subtotal removal of the right orbital mass presenting as right exophthalmos which was shown by histological examination to be non-Hodgkin''s lymphoma. He received 30 Gy Lineac irradiation to the right orbit. His postoperative course was satisfactory. Magnetic resonance (MR) imaging with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) 7 months later demonstrated a small spotty enhanced lesion in the left frontal lobe. He developed motor aphasia 1 year after irradiation. MR imaging disclosed an enhanced mass in the left frontal lobe, which was totally removed. Histological examination revealed glioblastoma multiforme. Patients with malignant lymphoma may develop a subsequent second malignant tumor. MR imaging with Gd-DTPA is quite useful for early detection of a second brain tumor.

Journal

  • Neurologia medico-chirurgica

    Neurologia medico-chirurgica 36(1), 11-14, 1996-01-15

    The Japan Neurosurgical Society

References:  23

Codes

  • NII Article ID (NAID)
    110002278753
  • NII NACSIS-CAT ID (NCID)
    AN00358613
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    04708105
  • Data Source
    CJP  NII-ELS  J-STAGE 
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