Results of Transsphenoidal Surgery for Growth-Hormone Secreting Pituitary Adenomas

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  • SAITOH Youichi
    Department of Neurosurgery, Osaka University Medical School
  • MORI Shintaro
    Department of Neurosurgery, The Center for Adult Diseases
  • ARITA Norio
    Department of Neurosurgery, Osaka University Medical School
  • HAYAKAWA Toru
    Department of Neurosurgery, Osaka University Medical School
  • MOGAMI Heitaro
    Department of Neurosurgery, Osaka University Medical School
  • OHTA Masahiro
    Department of Neurosurgery, Hiroshima University School of Medicine
  • Uozumi Tohru
    Department of Neurosurgery, Hiroshima University School of Medicine

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A total of 52 patients with growth-hormone (GH) secreting adenoma were treated by transsphenoidal microsurgery. The procedure, as a rule, consisted of complete debridement of tumorous tissue while preserving as much normal pituitary tissue as possible. In 47 of the 52 patients (90%), the blood GH level was normalized, and the abnormal response of blood GH level to TRH and LH-RH disappeared after surgery in 25 out of 37 cases (68%). In all 16 patients with diabetes mellitus, a complete cure or improvement was observed and the five cases with bitemporal hemianopsia showed improvement of the visual acuity and the visual field.

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