Preparation of Glass-Ceramics Containing Ferrimagnetic Zinc-Iron Ferrite for the Hyperthermal Treatment of Cancer

• KAWASHITA Masakazu

  Ion Beam Engineering Experimental Laboratory, Graduate School of Engineering, Kyoto University

• IWAHASHI Yasutomi

  Department of Material Chemistry, Graduate School of Engineering, Kyoto University

• KOKUBO Tadashi

  Research Institute for Science and Technology, Chubu University

• YAO Takeshi

  Department of Fundamental Energy Science, Graduate School of Energy Science, Kyoto University

• HAMADA Sunao

  Institute for Chemical Research, Kyoto University

• SHINJO Teruya

  Institute for Chemical Research, Kyoto University

Bibliographic Information

Other Title

• がん温熱治療用亜鉛-鉄フェライト含有強磁性結晶化ガラスの作製

Abstract

Ferrimagnetic glass-ceramics are useful as thermoseeds for hyperthermal treatment of malignant tumors, especially those located in deep parts of the body, since hysteresis loss heating occurs locally at the cancer site when they are implanted around the tumor and subjected to an alternating magnetic field. In the present study, glass-ceramic powders containing a large amount of fine particles of zinc-iron ferrite (Zn_xFe_3-xO₄) in a CaO-SiO₂-based glassy matrix were prepared by the heat treatment of ZnO-Fe₂O₃-CaO-SiO₂ glasses at various temperatures for 1 h in a 95CO₂+5H₂ atmosphere. The Zn_xFe_3-xO₄ precipitated above 700°C, and its crystallite size and fraction increased with increasing heat-treatment temperature, reaching 130 nm and 37 mass% at 1150°C, respectively. The saturation magnetization of the specimen increased to 38.4 emu•g^-1 with increasing heat-treatment temperature up to 1150°C. The coercive force of the specimen increased to 167.6 Oe at 1000°C, and then decreased with increasing heat-treatment temperature. When the heat-treatment period at 1150°C in a 95CO₂+5H₂ atmosphere was increased from 1 to 5 h, the content of Zn_xFe_3-xO₄ was not changed, whereas the crystallite size of Zn_xFe_3-xO₄ increased from 130 to 170 nm. The saturation magnetization and coercive force of the powders heat treated at 1150°C for 5 h in a 95CO₂+5H₂ atmosphere were 26.5 emu•g^-1 and 150.5 Oe, respectively. The prepared glass-ceramic powders showed a large amount of heat generation of 12.4 W•g^-1, under conditions of 300 Oe and 100 kHz.<br>

Journal

• Journal of the Ceramic Society of Japan

  Journal of the Ceramic Society of Japan 112 (1307), 373-379, 2004

  The Ceramic Society of Japan

Keywords

• Ferrimagnetism
• Glass-ceramics
• Zn_<i>x</i>Fe_3-<i>x</i>O₄
• Hysteresis loss
• Hyperthermia

Details

• CRID: 1390282680226383616
• NII Article ID: 110002288225
• NII Book ID: AN10040326
• DOI: 10.2109/jcersj.112.373
• COI: 1:CAS:528:DC%2BD2cXmtF2rtrw%3D
• ISSN: 18821022
• ISSN: 09145400
• NDL BIB ID: 7020904
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7020904
• Web Site: http://www.jstage.jst.go.jp/article/jcersj/112/1307/112_1307_373/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed