Nonrandom distribution of chromosome breaks in lymphocytes of atomic bomb survivors.
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The distribution of breakpoints within chromosomes in lymphocytes of 39 healthy atomic bomb survivors who were heavily exposed were studied by means of G and Q-banding techniques. A total of 1, 414 breakpoints in 651 cells with structural chromosome aberrations were used for the present analyses. The results obtained were as follows: (1) In chromosomes #15, #18 and #22, the breaks were more frequently observed than expected. On the contrary, the number of breaks among chromosomes #1, #2 and X was less than expected. (2) A higher incidence of breakpoints according to the length of regions in 4q3, 5q3 and 14q3 and a lower incidence in regions around centromeres of large chromosomes were observed. (3) Distribution of breakpoints was 26.6% in the centromeric region, 30.8% in the middle region and 42.6% in the telomeric region. (4) Seventy-four percent of the breaks was observed in the negative bands. The present results clearly show that breakpoints in atomic bomb survivors were not randomly distributed interchromosomally as well as intrachromosomally. Detailed chromosome analyses have elucidated the biological significance of chromosome aberrations particularly in relation to the late effects among atomic bomb survivors.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 24 (4), 291-304, 1983
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680192198016
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- NII論文ID
- 110002325873
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:BiuB3MngsFc%3D
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- ISSN
- 13499157
- 04493060
- http://id.crossref.org/issn/04493060
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- PubMed
- 6676466
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可