Timing in Administration of a Heat-killed Lactobacillus casei Preparation for Radioprotection in Mice.
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- 常岡 和子
- 放射線医学総合研究所薬理化学研究部
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- ISHIHARA HIROSHI
- Division of Chemical Pharmacology, National Institute of Radiological Sciences
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- DIMCHEV ALEXANDER BORRISOV
- Division of Chemical Pharmacology, National Institute of Radiological Sciences
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- NOMOTO KOJI
- Yakult Central Institute for Microbiological Research
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- YOKOKURA TERUO
- Yakult Central Institute for Microbiological Research
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- SHIKITA MIKIO
- Division of Chemical Pharmacology, National Institute of Radiological Sciences
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A single subcutaneous injection of a preparation of heat-killed Lactobacillus casei (LC 9018), given before or after irradiation, significantly increased the survival rate of mice that had received 8.5-Gy 137Cs whole-body γ-irradiation. A similar radioprotective effect was observed when LC 9018 was administered within the period from 2 days before irradiation to 9 h after irradiation, the pre-irradiation treatment being slightly better than the post-irradiation treatment. Increases in the weight of the spleen and in the number of endogenous spleen colonies on days 8 and 12 after irradiation suggested that the radioprotective effect was based on enhanced recovery of hematopoietic tissues. The activity of macrophage colony-stimulating factor (M-CSF) in serum was rapidly increased by the treatment and was maintained at the elevated level for 13 days. At the same time, an increased level of M-CSF mRNA was detected in the livers of the treated mice. However, LC 9018 failed to save the lives of mice when administered 3 days after irradiation, although it increased serum M-CSF as effectively as noted above. The small advantage of the pre-irradiation over the post-irradiation treatment was not explained by the increases of metallothionein in the hematopoietic tissues of the treated mice.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 35 (3), 147-156, 1994
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205214939776
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- NII論文ID
- 110002328059
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- NII書誌ID
- AA00705792
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- COI
- 1:CAS:528:DyaK2MXisVejt74%3D
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- ISSN
- 13499157
- 04493060
- http://id.crossref.org/issn/04493060
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- PubMed
- 7830258
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- 使用不可