Drinking Beer Reduces Radiation-induced Chromosome Aberrations in Human Lymphocytes.
-
- MONOBE MANAMI
- Graduate School of Science and Technology, Chiba University Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences
-
- ANDO KOICHI
- Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences
この論文をさがす
抄録
We here investigated and reported the effects of beer drinking on radiation-induced chromosome aberrations in blood lymphocytes. Human blood that was collected either before or after drinking a 700 ml beer was in vitro irradiated with 200 kVp X rays or 50 keV/μm carbon ions. The relation between the radiation dose and the aberration frequencies (fragments and dicentrics) was significantly (p < 0.05) lower for lymphocytes collected 3 h after beer drinking than those before drinking. Fitting the dose response to a linear quadratic model showed that the alpha term of carbon ions was significantly (p < 0.05) decreased by beer drinking. A decrease of dicentric formation was detected as early as 0.5 h after beer drinking, and lasted not shorter than 4.5 h. The mitotic index of lymphocytes was higher after beer drinking than before, indicating that a division delay would not be responsible for the low aberrations induced by beer drinking. An in vitro treatment of normal lymphocytes with 0.1 M ethanol, which corresponded to a concentration of 6-times higher than the maximum ethanol concentration in the blood after beer drinking, reduced the dicentric formation caused by X-ray irradiation, but not by carbon-ion irradiation. The beer-induced reduction of dicentric formation was not affected by serum. It is concluded that beer could contain non-ethanol elements that reduce the chromosome damage of lymphocytes induced by high-LET radiation.<br>
収録刊行物
-
- Journal of Radiation Research
-
Journal of Radiation Research 43 (3), 237-245, 2002
Journal of Radiation Research 編集委員会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205216469632
-
- NII論文ID
- 110002328788
-
- NII書誌ID
- AA00705792
-
- COI
- 1:STN:280:DC%2BD3s%2Fht1Khug%3D%3D
-
- ISSN
- 13499157
- 04493060
-
- NDL書誌ID
- 6451821
-
- PubMed
- 12518984
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可