Changes in HistologicaI Construction and Decrease in 3H-QNB Binding in the Rat Brain after PrenataI X-irradiation

• MOMOSAKI SOTARO

  Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University

• SUN XUE-ZHI

  Brain Research Project, National Institute of Radiological Sciences

• TAKAI NOBUHIKO

  Brain Research Project, National Institute of Radiological Sciences

• HOSOI RIE

  Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University

• INOUE OSAMU

  Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University

• TAKAHASHI SENTARO

  Brain Research Project, National Institute of Radiological Sciences

書誌事項

タイトル別名

• Changes in Histological Construction and Decrease in 3H-QNB Binding in the Rat Brain after Prenatal X-irradiation.

抄録

To elucidate the mechanisms involved in deleterious neuronal and behavioral changes after prenatal ionizing irradiation, in vitro muscarinic acetylcholine (mACh) receptor binding and histological construction were investigated in 9-week old rat brains after 1.5 Gy X-ray exposure on embryonic day 15 (E15). A gross anatomical examination with a magnetic-resonance imaging system showed an irregular tissue construction in the hippocampus and cortex of the irradiated rat brain. Histological sections stained with hematoxylin and eosin also indicated that the structures of the hippocampus and cortex were obviously changed. In irradiated rats, the laminar structure of pyramidal cells was selectively deranged in the CA1 region. In vitro ³H-Quinuclidinyl benzilate binding in the hippocampus was significantly decreased (about 10%) in prenatal irradiated rats compared to that in sham-treated rats. On the other hand, no significant change in mACh receptor binding was observed in the cerebral cortex. The present study revealed that prenatal exposure to ionizing radiation may induce dysfunction of the cholinergic neuronal systems, especially in the hippocampus, resulting in deleterious changes in memory and behavior.<br>

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 43 (3), 277-282, 2002

  Journal of Radiation Research 編集委員会

キーワード

• X-irradiation
• Hippocampus
• Histological change
• MRI
• Muscarinic acetylcholine receptor binding

詳細情報

• CRID: 1390001205216433024
• NII論文ID: 110002328792
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.43.277
• COI: 1:CAS:528:DC%2BD38XptVKhtb4%3D
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 6451941
• PubMed: 12518987
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6451941
• Web Site: http://academic.oup.com/jrr/article-pdf/43/3/277/2831682/jrr-43-277.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10917693
• Web Site: https://search.jamas.or.jp/link/ui/2003118124
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • NDL-Digital
  • CiNii Articles
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