Effects of X-ray Irradiation on Genomic DNA Methylation Levels in Mouse Tissues.

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  • TAWA RIICHI
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
  • KIMURA YUTAKA
    Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University Department of Microbiology and Immunology, Graduate School of Medicine, Tohoku University
  • KOMURA JUN-ICHIRO
    Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University
  • MIYAMURA YOSHINORI
    Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University Present address: Department of Dermatology, School of Medicine, Nagoya University
  • KURISHITA AKIHIRO
    Procter & Gambler, Far East, Inc.
  • SASAKI MASAO S.
    Radiation Biology Center, Kyoto University
  • SAKURAI HIROMU
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
  • ONO TETSUYA
    Section of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University

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Abstract

Effects of ionizing radiation on the level of genomic DNA methylation in liver, brain and spleen of mouse as well as in two kinds of cultured cells were examined by high-performance liquid chromatography. Ten Gy of whole body X-radiation reduced the 5-methyldeoxycytidine contents by about 40% within 8 hours after irradiation in liver. Similar effects were observed at 4 or 7 Gy of X-ray irradiation. However, no such change was detected in brain, spleen and cultured cells. The data indicate that radiation-induced alteration in genomic DNA methylation is not ubiquitous among different tissues and cells.

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