線維芽細胞が発現する引張応力と自己組織化　培養系における実験的検討

• 高久田 和夫

• 宮入 裕夫

書誌事項

タイトル別名

• Tension Induced by Fibroblasts and Automorphogenesis. An in vitro Study.
• センイ ガサイボウ ガ ハツゲンスル ヒッパリ オウリョク ト ジコ ソシキカ

抄録

Tensile stress field induced by fibroblasts in collagen gel are investigated by the cell culture method. Specimens of thin collagen gel membrane, within which cells proliferate, are subjected to various initial and boundary conditions, and cell stretching, cell orientation, cell migration, cell proliferation, induction of tensile stress field in collagen gel, and geometry transformation of specimens are observed. It is demonstrated that fibroblasts induce tension, change their orientation along the tensile direction, and create structures composed of collagen fibers. A hypothetical mechanism for such automorphogenesis is proposed wherein fibroblasts induce tension and produce tense collagen fibers. Cells then stretch along the tense fibers, which increases tension in this direction. Thus this mechanism functions as a positive feedback loop which enables cells to form structures with collagen fibers according to the mechanical environment.

収録刊行物

• 日本機械学会論文集Ａ編

  日本機械学会論文集Ａ編 62 (595), 800-807, 1996

  一般社団法人 日本機械学会

キーワード

• Medical Engineering
• Biomaterials
• Cell Culture
• Fibroblasts
• Collagen
• Fibrous Structures
• Tensile Stress Field
• Automorphogenesis

詳細情報

• CRID: 1390282679424776064
• NII論文ID: 110002372676
• NII書誌ID: AN0018742X
• DOI: 10.1299/kikaia.62.800
• ISSN: 18848338
• ISSN: 03875008
• NDL書誌ID: 3934548
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3934548
• Web Site: http://www.jstage.jst.go.jp/article/kikaia1979/62/595/62_595_800/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可