和漢薬「小青竜湯」の抗アレルギー作用特に既製抗アレルギー剤との比較  [in Japanese] A COMPARISION BETWEEN CHINESE BLENDED MEDICINE"SHOSEIRYUTO", TRANILAST AND KETOTIFEN ON THE ANTI-ALLERGIC ACTION IN THE GUINEA PIGS  [in Japanese]

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Abstract

小青竜湯は8種類の生薬から種成される漢方方剤で, アレルギー疾患の予防または治療に適用されている.しかし本剤の薬理作用および効果については報告が少ない.本研究はアレルギー抑制機作を知るために既存の経口抗アレルギー剤であるtranilastおよびketotifenと比較することにより本剤の薬理作用の解析を試みることを目的とし, 以下の成績をえた.1.ヒトの常用量から換算された量をモルモットに投与し, 2または3時間後にPCAに及ぼす影響を観察した結果, 3剤とも同程度の抑制傾向を示した.2.10日間連続投与後1または3日の中止後に全身性アナフィラキシーを惹起した.その結果, いずれの薬剤も投与によりショック症状の発現および血中ヒスタミンの増加は認められなかった.3.ヒスタミン, セロトニン, アセチルコリンの皮内注射による皮膚反応に対する各薬剤の拮抗作用は各々異なり, 小青竜湯はヒスタミン, セロトニン, アセチルコリンによる皮膚反応をすべて抑制したが, tranilastはヒスタミンによる皮膚反応を抑制せず, ketotifenはアセチルコリンおよびセロトニンによる皮膚反応を抑制しなかった.以上の結果から, 小青竜湯はtranilastおよびketotifenと薬理作用は異なるが同程度の抗アレルギー効果を有することが示唆された.

Shoseiryuto, Chinese blended medicine consisting of eight crude drugs, seems to be an effective drug for the treatment and prevention of allergic disease. However, little information is available on its pharmacological action and clinical effects. The purpose of this paper is to investigate the pharmacological action of shoseiryuto in more detail by comparing experimental results with those obtained by tranilast and ketotifen. The results obtained were as follows. 1. Shoseiryuto (83 mg/kg), tranilast (1.65 mg/kg) and ketotifen (0.015 mg/kg) were orally administrated 2 or 3 hrs before antigen challenge inducing IgE mediated PCA. The results showed that these 3 drugs have a similar suppressing effect on the induction of PCA. 2. Guinea pigs were treated with each compound for 10 days successively and on the day they were passively sensitized with IgE antibody. On day 1 or 3 after discontinuance of the treatment, the challenging antigen was injected intravenously, but systemic anaphylactic shock was not elicited in all cases. Also no change of histamine levels in blood was observed compared with the samples before and after eliciting. 3. The suppressing effect of these durgs on histamine, serotonin and acetylcholine inducing inflammatory reactions were compared. Shoseiryuto showed a inhibitory effect on histamine, serotonin and acetylcholine induced inflammatory reactions while tranilast did not inhibit histamine induced reaction and ketotifen did not inhibit acetylcholin and serotonin induced reactions. From these results, it was indicated that the anti-allergic effect of shoseiryuto is about the same as that of the other two drugs, while the pharmacological effect seems to be differ from that of tranilast and ketotifen.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 34(6), 387-393, 1985

    Japanese Society of Allergology

Cited by:  9

Codes

  • NII Article ID (NAID)
    110002414167
  • NII NACSIS-CAT ID (NCID)
    AA00518456
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021-4884
  • Data Source
    CJPref  NII-ELS  J-STAGE 
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