気管支喘息と自己抗体  [in Japanese] AUTOANTIBODIES IN BRONCHIAL ASTHMA  [in Japanese]

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Abstract

アトピー型喘息(ABA) 20例, 非アトピー型喘息(NABA) 15例, 肺癌(LC) 20例, 他の肺疾患(PD) 40例, 他の内科疾患(OD) 63例を対象に抗核抗体(ANA, 間接蛍光抗体法, 40倍以上を陽性とした)検出の有無を検討した. ABAでは4/20例に, NABAでは8/15例に, LCでは6/20例に, PDでは5/40例に, ODでは7/63例にANAを検出した. NABAでは, 年齢, 性別を考慮しても, 有意に自己抗体が検出された. NABAでは, 主としてリンパ球や好酸球が浸潤する慢性好酸球性気道炎症に加え, ウイルス感染などによる気道炎症も加わり, 自己抗原の暴露が起ニり, 加齢による免疫異常も影響して, 抗核抗体産生を起こしやすいのかもしれない.

We studied the difference in the prevalence of autoantibodies between the sera of atopic asthma and non-atopic asthma. The presence of antinuclear antibodies (ANA) was evaluated in the sera of 20 patients with atopic asthma, 15 with non-atopic asthma, 20 with lung cancer, and 103 control subjects (40 with other pulmonary diseases and 63 with other medical diseases), by using an indirect immunofluorescent assay with HEp-2 cells as a substrate. The incidence of positive ANA was in the sera of 4/20 patients with atopic asthma, 8/15 with non-atopic asthma, 6/20 with lung cancer and 12/103 with control subjects, respectively. The incidence of positive ANA was found to be significantly higher in non-atopic asthma than in atopic asthma regardless of age or sex. One hypothesis is as follows. In non-atopic asthma, viral airway infection, as well as chronic eosinophilic inflammation of the airways, may cause some trouble in the impaired lymphocyte surveillance and may be especially liable to develope autoantibodies under those circumstances.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 45(7), 655-659, 1996

    Japanese Society of Allergology

References:  20

Codes

  • NII Article ID (NAID)
    110002418343
  • NII NACSIS-CAT ID (NCID)
    AN00012583
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    0021-4884
  • Data Source
    CJP  NII-ELS  J-STAGE 
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