INCREASED SERUM LEVELS OF SOLUBLE INTERLEUKIN 2 RECEPTOR IN PATIENTS WITH DRUG-INDUCED ALLERGIC HEPATITIS

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  • Onji Morikazu
    Third Department of Internal Medicine, Ehime University School of Medicine
  • Masumoto Toshikazu
    Third Department of Internal Medicine, Ehime University School of Medicine
  • Ohta Yasuyuki
    Third Department of Internal Medicine, Ehime University School of Medicine

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  • 薬物アレルギー性肝炎における血中可溶型インターロイキン2レセプター

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Abstract

Soluble interleukin 2 receptor (sIL2R) level in the serum of 10 patients with drug-induced allergic hepatitis (DIAH) were quantified with a solid-phase enzyme immunoassay using two monoclonal antibodies against the receptor. The sIL2R levels in patients with DIAH were significantly higher than in 15 normal subjects (p<0.01). The high sIL2R levels observed during the florid stage of DIAH returned to normal during convalescence (p<0.05). SIL2R trom the serum of DIAH patients was found to bind to a recombinant IL2 affinity column. It seems likely that sIL2R inhibits the hyper-immune reaction that occurs in drug allergies due to bind IL2. But, we have no data that sIL2R inhibits actually the biological activity of IL2.

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