同時多項目特異IgE測定法MAST-26の臨床的有用性に関する検討  [in Japanese] EVALUATION OF MAST-26, NEWLY DEVELOPED SYSTEM FOR THE DETECTION OF IgE ANTIBODIES  [in Japanese]

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Abstract

MAST-26は, 血清量200μlで26項目のアレルゲンに対する特異IgEを同時に測定できる新しい評価方法である.今回MAST-26のアレルゲン特異IgE抗体のスクリーニング法としての有用性を検討するため, 5施設から得たアレルギー疾患患者100人の血清を対象としてMAST-26による特異IgEの測定を行った.その結果, 全患者の14%で同時に10種類以上のアレルゲンが陽性と判定された.また, 全症例を重症度別に分類した場合, 重症度が高い患者ほど, より多くのアレルゲンに対し陽性を示す傾向が認められた.CAP RASTとの相関を検討した結果, 多くの項目でCAP RASTと良好な相関を示した.また, 皮内試験との相関についても高い一致率を示した.以上より, MAST-26は特異IgEのスクリーニング検査として有用であると考えられた.

MAST-26 is a new allergy testing system which allows simultaneous determination of allergen-specific IgE antibody levels for 26 allergens using 200 μl of patient serum. To evaluate the effectiveness of MAST-26 for the detection of allergen-specific IgE antibody, a total of 100 serum samples were collected from allergic patients at five facilities, and allergen-specific IgE antibody was measured by MAST-26.14% of them were positive to ≧10 allergens. If the patients had severe allergic symptoms, they were likely to show positive to many allergens. A good correlation wa found between the results obtained by MAST-26 with those measured by CAP RAST and by intradermal skin test. It was concluded that MAST-26 is an effective screening method for the detection of allergen-specific IgE.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 49(4), 335-344, 2000

    Japanese Society of Allergology

References:  13

Cited by:  8

Codes

  • NII Article ID (NAID)
    110002426379
  • NII NACSIS-CAT ID (NCID)
    AN00012583
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021-4884
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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