Food-Dependent Exercise-Induced Anaphylaxis(FDEIA)の本邦報告例集計による考察  [in Japanese] A STUDY OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS BY ANALYZING THE JAPANESE CASES REPORTED IN THE LITERATURE  [in Japanese]

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Abstract

food-dependent exercise-induced anaphylaxisの本邦報告例167例を集計し, その臨床的特徴の解析を行った. その結果, 1)本症は男性特に10歳代に好発する, 2)原因食物は小麦が最多で次いでエビであるが, 20歳未満の症例ではエビが最多となる, 3)原因食物に対する即時型アレルギー検査は大部分で陽性を示し, 基本的にI型アレルギーに基づく反応と考えられる, 4)約40%の症例でアトピー性疾患の既往ないし合併を認め, 両者間には関連性があると考えられる, 5)誘発試験にアスピリンを加えたすべての症例でアスピリンの関与が認められ, アスピリンは本症の増悪因子として作用している可能性がある, 6)本症の報告は年次毎に増加傾向を認めている, 7)学童の昼食後の昼休みないし5時間目の体育の授業中での発症例が17例(10.2%)ある等の特徴が認められ, これらの結果から特に学校関係者に対し本症に関する知識を啓蒙する必要があると考えられた.

We surveyed and analyzed cases of food-dependent exercise-induced anaphylaxis(FDEIA)in the Japanese literature. We found 167 cases which were reported as FDEIA since 1983. Analyzing these cases, following characteristic features were revealed: 1)Recent upward trend in the number of reports of FDEIA was noted. 2)Male cases were more frequent than female cases, while about half of the cases were teenager. 3)More than half of the cases were proved to be induced by wheat followed by shrimp. In those under 20, shrimp was the most popular cause rather than wheat. 4)Skin test and/or IgE RAST showed positive results in most cases, suggesting that the response itself is linked to type I allergic reaction. 5)About 40% of the patients had history of atopic disease, indicating that atopic condition may play some role in FDEIA. 6)All cases who performed provocation test with aspirin responded to food challenge and/or exercise in combination with aspirin. This indicates that aspirin plays a key provoking factor in FDEIA. 7)In 17 cases FDEIA attacks were observed during noon recess or physical education class after lunch at school. We stress here the importance of a nation-wide education to school teachers the potential danger of this disorder.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 49(11), 1066-1073, 2000

    Japanese Society of Allergology

References:  37

Cited by:  33

Codes

  • NII Article ID (NAID)
    110002426414
  • NII NACSIS-CAT ID (NCID)
    AN00012583
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    0021-4884
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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