STUDY OF COCKROACH ALLERGEN IN ADULT ASTHMATICS IN JAPAN

成人気管支喘息患者におけるゴキブリアレルゲンの検討 [in Japanese] STUDY OF COCKROACH ALLERGEN IN ADULT ASTHMATICS IN JAPAN [in Japanese]

- 冨田尚吾 Tomita Shougo
- 昭和大学藤が丘病院呼吸器内科:国立相模原病院臨床研究センター Dept. of Respiratory Medicine, Fujigaoka Hospital of Showa University School of Medicine:Research Center for Reumato-Allergology, National Sagamihara Hospital
- 鈴木一 Suzuki Hajime
- 昭和大学藤が丘病院呼吸器内科 Dept. of Respiratory Medicine, Fujigaoka Hospital of Showa University School of Medicine
- 秋山一男 Akiyama Kazuo
- 国立相模原病院臨床研究センター Research Center for Reumato-Allergology, National Sagamihara Hospital

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Author(s)

- 冨田尚吾 Tomita Shougo
- 昭和大学藤が丘病院呼吸器内科:国立相模原病院臨床研究センター Dept. of Respiratory Medicine, Fujigaoka Hospital of Showa University School of Medicine:Research Center for Reumato-Allergology, National Sagamihara Hospital
- 鈴木一 Suzuki Hajime
- 昭和大学藤が丘病院呼吸器内科 Dept. of Respiratory Medicine, Fujigaoka Hospital of Showa University School of Medicine
- 秋山一男 Akiyama Kazuo
- 国立相模原病院臨床研究センター Research Center for Reumato-Allergology, National Sagamihara Hospital

Abstract

成人気管支喘息患者127名においてコマーシャルベースの4種のゴキブリ抗原液を用いて皮内テストを行った.またCAP-RAST法にてゴキブリ特異的IgE抗体を測定した.使用したゴキブリ抗原液に対する即時型皮内反応陽性率は10.2〜12.6%であり,CAP-RAST陽性率は12.6%であった.ゴキブリに感作された喘息患者6名にゴキブリによる抗原吸入誘発試験を施行したところ2名に即時型気道反応,1名に遅発型気道反応を認めた.末梢血白血球ヒスタミン遊離試験においても陽性例を認めた.RAST抑制試験にて2種のゴキブリ(American cockroach, German cockroach)の間には共通抗原性の存在が示唆された.またダニ抗原によってもゴキブリRASTは抑制される例がみられ,一部ダニとの共通抗原性も示唆された本邦においてもゴキブリアレルゲンの関与した喘息症例は少なからず存在し,注目すべきと思われた.

To study the clinical significance of cockroach allergen in adult asthmatics in Japan, we performed intradermal skin test to four commercial base cockroach extracts. The specific IgE antibody to cockroach was measured in sera by CAP-RAST. Positive rates of immediate intradermal skin response to cockroach extracts were 10.2〜12.6%. Positive rate of CAP-RAST to cockroach was 12.6%. We performed bronchial provocation test on 6 cockroach sensitive asthmatics. Immediate asthmatic response was provoked in 2 cases and late asthmatic response was provoked in one case. Positive histamine release from peripheral leukocytes (HRT) to cockroach was shown in cockroach sensitive asthmatics. RAST-inhibition studies of cockroach showed several inhibition patterns and indicated partial cross-reactivity between cockroach species and mite. These results indicate that there is a possibility that cockroach is one of the important inhalent allergens in Japan.

Journal

Japanese Journal of Allergology

Japanese Journal of Allergology 51(5), 430-438, 2002

Japanese Society of Allergology

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成人気管支喘息患者におけるゴキブリアレルゲンの検討 [in Japanese] STUDY OF COCKROACH ALLERGEN IN ADULT ASTHMATICS IN JAPAN [in Japanese]

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