アルコール (飲酒) 誘発喘息に及ぼす各種抗喘息薬の抑制効果に関する研究  [in Japanese] THE INHIBITORY EFFECTS OF ANTI-ASTHMATIC AGENTS ON ETHANOL-INDUCED BRONCHOCONSTRICTION IN JAPANESE ASTHMATIC PATIENTS  [in Japanese]

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Abstract

飲酒によっておこる気道収縮反応は, 日本人喘息患者の約半数に認められる反応で, 臨床上重要な増悪因子のひとつである. 今回我々は, このアルコール (飲酒) 誘発喘息の機序を明らかにする目的で, 成人喘息患者6名に対して, 種々の抗喘息薬で前処置したうえでエタノール経口負荷試験を行い, その抑制効果を検討した. 抗ヒスタミン作用を有するcyproheptadine hydrochloride 8mgの経口投与はエタノール負荷120分後の反応を有意に抑制し, disodium cromoglycate 2mgの吸入は負荷後15分から30分の反応を有意に抑制した. 一方atropine sulfate 3mgの吸入は抑制効果を示さなかった. これらの結果から, アルコール (飲酒) 誘発喘息の機序には肥満細胞 (好塩基球) とヒスタミンが関与していることが示唆された. しかし今回検討した6症例に関して, 薬剤の抑制効果は必ずしも同一ではなく, 本症は単一の化学伝達物質を介する反応ではなく, 複雑な反応の結果起こっていることも考えられ, さらに検討が必要と思われた.

Asthmatic symptoms are worsened after drinking small amounts of alcoholic beverages in Japanese asthmatic patients. Our previous results showed that the ingestion of pure ethanol caused a fall in FEV_<1.0> in about half of the Japanese asthmatics we studied. We studied the inhibitory effects of pretreatment with three kinds of anti-asthmatic agents on ethanol-induced bronchoconstriction in six Japanese asthmatic patients. We tested oral cyproheptadine hydrochloride (8 mg), which is an anti histamine agent, inhaled disodium cromoglycate (2 mg), which has an inhibitory effect on the release of chemical mediators from mast cells, and inhaled atropine sulfate (3 mg), which is an anti-cholinergic agent. Pretreatment with cyproheptadine significantly inhibited the fall in FEV_<1.0> 120 minutes after ethanol challenge (p<0.05). Inhaled DSCG had significant inhibitory effects on the fall in FEV_<1.0> 15 and 30 minutes after ethanol challenge (p<0.05). Inhaled atropine had no inhibitory effect. These results suggest that histamine, released from mast cells, plays an important role in ethanol induced bronchoconstriction in Japanese asthmatic patients.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 41(7), 720-726, 1992

    Japanese Society of Allergology

Codes

  • NII Article ID (NAID)
    110002431304
  • Text Lang
    JPN
  • ISSN
    0021-4884
  • Data Source
    NII-ELS  J-STAGE 
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