F-0823 肥厚性血管病の進展による血管内腔形状の経時的変化の数値シミュレーション(S43-6 循環系の数値シミュレーション(3))(S43 生体力学シミュレーション)

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  • F-0823 Computer Simulation of the Time Course of the Change in Vascular Geometry Caused by the Development of Atherosclerosis

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In order to investigate the effects of hemodynamic factors on the development of vascular diseases such as atherosclerosis and intimal hyperplasia, we carried out a computer simulation of the change in the shape of the luminal surface of a stenosed artery by increasing the thickness of the wall step by step based on the distribution of wall shear stress which was obtained by the calculation for steady flow through the artery at each step to maintain the value of wall shear stress within a certain range. It was assumed that the blood vessel is thickened at the site where wall shear stress is lower than a certain threshold value and then the nodal points constituting the luminal surface of the vessel was shifted in the direction normal to the wall to correct the difference. As the results, it was found that intimal thickening progressed on both the proximal and distal sides of the stenosis where wall shear stresses were low in the stenosed artery at the initial state. However, the degree of the thickening was not determined directly from the value of the wall shear stress in the initial state but by the interaction of shape change of the artery and flow dynamics affected by it.

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