Effects of the Kampo medicine Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang) on the bone mass and serum levels of steroid hormones in ovariectomized adult rats

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  • SASSA,Shuji
    Department of Functional Genomics, Division of Functional Disorder Research, Medical Research Institute, Tokyo Medical and Dental University
  • SAKAMOTO,Shinobu
    Department of Functional Genomics, Division of Functional Disorder Research, Medical Research Institute, Tokyo Medical and Dental University
  • MITAMURA,Tadasu
    Department of Functional Genomics, Division of Functional Disorder Research, Medical Research Institute, Tokyo Medical and Dental University
  • SHINODA,Hisashi
    Department of Pharmacology, School of Dentistry, Tohoku University

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  • 成熟去勢雌ラットに対する漢方薬補中益気湯の骨ならびにステロイドホルモンへの影響

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Abstract

Kampo medicines Hochu-ekki-to (HET) has been used at the convalescent stage after diseases or surgery, and for the treatment of patients with tuberculosis, appetite loss and gastroptosis. Recently, it was reported that HET cured bone loss induced with the absorption disorder of calcium from the gastrointestinal tracts in the gastrectomized patients. In the present study, we investigated the effects of HET on the bone mineral density in the senior ovariectomized rats. Sprague-Dawley female rats were castrated at the age of 9 weeks and given HET (50 mg/100 g of body weight/day : Tsumura Co., Tokyo) suspended in distilled water by gastric tubes from the age of 35 weeks for 8 weeks. Control animals were given distilled water alone as a control vehicle. Oral administration of HET Ied to the increase of serum alkaline phosphatase activity which indicated the activity of bone metabolism, and significantly augmented the serum levels of progesterone (P_4) and estradiol (E_2) despite the ovariectomized rats. In fact, the bone mineral density was significantly enhanced in the whole and metaphysis of tibia. These findings may indicate that HET augments the bone mineral density, which is influenced by elevated serum estradiol levels, and are led by the activation of aromatization on dehydroepiandrosterone sulfate, that is metabolized from progesterone, of which synthesis is accelerated in adrenal.

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