Antidiabetogenic constituents from Salacia species(Chemical & Pharmacological study)
In the course of our studies on antidiabetogenic compounds from natural medicines and medicinal foodstuffs, we found that the extracts from the roots and stems of Salacia reticulata, S. oblonga, and S. chinensis showed substantial inhibitory effects on increase in serum glucose levels in oral sucrose- and maltose-loaded rats and inhibitory effects on intestinal α-glucosidase. Through bioassay-guided separation using α-glucosidase inhibitory activities, we isolated α-glucosidase inhibitors named salacinol and kotalanol with unique chemical structures from the active fractions together with several known phenolic compounds, new sesquiterpenes (salasols A and B) and triterpenes (kotalagenin 16-acetate, salasones A-E, salaquinones A and B). Furthermore, S. reticulata and its phenolic constituents were found to exhibit pancreatic lipase inhibitory and anti-obese effects. This paper summarizes our recent studies including the synthetic and structure-activity relationships on antidiabetogenic principles of Salacia species. In addition, clinical studies and safety evaluations of the extracts from S. reticulata and S. oblonga are summarized.
和漢医薬学雑誌 22(Supplement_1), 145-153, 2005