Dipyridamole Suppresses Catecholamine-and Ca<sup>++</sup> Influx-Sensitive Ventricular Arrhythmias
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- Kobayashi Youichi
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Miyata Akira
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Chiyoda Kazumi
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Nakagawa Haruyuki
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Jinbo Yoshihiro
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Tanno Kaoru
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Kikushima Shuji
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Kurano Kozo
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Baba Takao
- The Third Department of Internal Medicine, Showa University School of Medicine
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- Katagiri Takashi
- The Third Department of Internal Medicine, Showa University School of Medicine
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抄録
To study the mechanism of ventricular arrhythmias, the effect of dipyridamole (DIP; 300 mg/day), an adenosine transport inhibitor, on ventricular premature contractions (VPCs) was assessed in 12 patients who showed VPCs (21312±12314/day) on Holter ECG in a controlled setting. The effects were compared with those of verapamil (240 mg/day) and bisoprolol (5 mg/day). DIP suppressed more than one-half the VPCs in 5 patients. The mean degree of reduction in these DIP-responders was 75±18%. Both verapamil and bisoprolol inhibited VPCs in all of the DIP-responders (verapamil: 71±15%, bisoprolol: 88±16%). Two of the 5 DIP-responders had sustained ventricular tachycardias (VT) that were terminated by intravenous DIP, ATP, acetylcholine, verapamil, and propranolol. In contrast, verapamil did not inhibit VPCs in any of the DIP-nonresponders. Bisoprolol also did not suppress VPCs in 3 of 6 DIP-non responders. Heart rate was unaffected by DIP, but was suppressed by both verapamil and bisoprolol. In addition, DIP increased the serum concentration of adenosine (control 16.3 ±17.1 vs 22.3±19.0 pmol/ml after DIP, p<0.05). The inhibitory effect of DIP may involve suppression of Ca++ current through an extracellular increase in adenosine. (Jpn Circ J 1996; 60: 629 - 640)
収録刊行物
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- JAPANESE CIRCULATION JOURNAL
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JAPANESE CIRCULATION JOURNAL 60 (9), 629-640, 1996
社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001206428625664
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- NII論文ID
- 110002560995
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- NII書誌ID
- AA00690731
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- COI
- 1:CAS:528:DyaK28XntlGrtL4%3D
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- ISSN
- 13474839
- 00471828
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- PubMed
- 8902581
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可