Quantitative evaluation of the rate of myocardial interstitial fibrosis using a personal computer QUANTITATIVE EVALUATION OF THE RATE OF MYOCARDIAL INTERSTITIAL FIBROSIS USING A PERSONAL COMPUTER

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Author(s)

    • KITAMURA Masaru
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • SHIMIZU Masami
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • KITA Yoshihito
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • YOSHIO Hiroyuki
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • INO Hidekazu
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • MISAWA Katsushi
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • MATSUYAMA Toru
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University
    • MABUCHI Hiroshi
    • Second Department of Internal Medicine, School of Medicine, Kanazawa University

Abstract

金沢大学大学院医学系研究科金沢大学大学院医学系研究科

We investigated the reliability and reproducibility of an image- analyzing system run on a personal computer for measurement of myocardial interstitial fibrosis. Measurements of myocardial interstitial fibrosis in right ventricular endomyocardial biopsies obtained from patients with hypertrophic cardiomyopathy determined by this image-analyzing system were compared with measurements determined by the point-counting method. We also investigated the correlation between measurements of interstitial fibrosis obtained by image analysis and biochemical measurements of myocardial levels of hydroxyproline in normal and cardiomyopathic hamsters. The intra- and interobserver variability were significantly lower for measurements obtained by the image-analyzing system than for measurements obtained by the point- counting system. Reproducibility was superior with the image-analyzing method. The rate of myocardial interstitial fibrosis determined by the computer image-analyzing method was positively correlated with the hydroxyproline measurement (r=0.89). Our results suggest that an image- analyzing system using a personal computer provides reproducible results with a high level of reliability.

Journal

  • Japanese Circulation Journal

    Japanese Circulation Journal 61(9), 781-784, 1997-08-20

    Japanese Circulation Society

References:  18

Cited by:  2

Codes

  • NII Article ID (NAID)
    110002564861
  • NII NACSIS-CAT ID (NCID)
    AA00690731
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00471828
  • Data Source
    CJP  CJPref  NII-ELS  IR 
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