Detecting Viable Hibernating Myocardium in Chronic Coronary Artery Disease

• Toyama Takuji

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

• Hoshizaki Hiroshi

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

• Isobe Naoki

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

• Adachi Hitoshi

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

• Naito Shigeto

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

• Oshima Shigeru

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

• Taniguchi Koichi

  Gunma Prefectural Cardiovascular Center, Maebashi, Japan

Bibliographic Information

Other Title

• - A Comparison of Resting <SUP>201</SUP>Tl Single Photon Emission Computed Tomography (SPECT), <SUP>99m</SUP>Tc-Methoxy-Isobutyl Isonitrile SPECT After Nitrate Administration, and <SUP>201</SUP>Tl SPECT After <SUP>201</SUP>Tl-Glucose-Insulin Infusion -

Abstract

To identify and quantify the amount of viable hibernating myocardium in patients with chronic coronary artery disease, resting ²⁰¹Tl single photon emission computed tomography (SPECT) was compared with ^99mTc-methoxyisobutyl isonitrile (MIBI) SPECT after nitrate infusion (nitrate-^99mTc-MIBI) and ²⁰¹Tl SPECT after ²⁰¹Tl with glucose-insulin-potassium infusion (²⁰¹Tl-GIK) in 25 patients. Twenty-one patients also underwent completely left ventriculography beforehand and 5±4 months afterwards. SPECT images were divided into 9 segments and scored visually from 0 (normal uptake) to 3 (absent). The defect score was calculated as the summation of the total scores (TDS) in each patient. The TDS of nitrate-^99mTc-MIBI images (6.3±4.3) and ²⁰¹Tl-GIK images (5.8±4.2) were significantly lower than the 7.4±4.3 of resting ²⁰¹Tl images (p<0.01). Based on the improvement of wall motion after coronary revascularization, the sensitivity of ²⁰¹Tl-GIK imaging (85%) was significantly higher (p<0.05), and that of nitrate-^99mTc-MIBI imaging (79%) also tended to be higher (p=0.08), than that of ²⁰¹Tl imaging (62%) in detecting viable myocardium. The specificity of the 3 methods was almost the same. The nitrate-^99mTc-MIBI and ²⁰¹Tl-GIK methods were more useful than the resting ²⁰¹Tl method for evaluating viable hibernating myocardium. Furthermore, the ²⁰¹Tl-GIK method may provide a more accurate estimate of the amount of viable myocardium than the nitrate-^99mTc-MIBI method.

Journal

• Japanese Circulation Journal

  Japanese Circulation Journal 64 (12), 937-942, 2000

  The Japanese Circulation Society

Keywords

• Hibernation
• Nitrate-<SUP>99m</SUP>Tc-MIBI
• <SUP>201</SUP>Tl-GIK
• <SUP>201</SUP>Tl-rest

Details

• CRID: 1390001206433870208
• NII Article ID: 110002571773
• NII Book ID: AA00690731
• DOI: 10.1253/jcj.64.937
• COI: 1:STN:280:DC%2BD3M3ls1Gnsg%3D%3D
• ISSN: 13474839
• ISSN: 00471828
• ISSN: http://id.crossref.org/issn/00471828
• PubMed: 11194287
• Web Site: http://www.jstage.jst.go.jp/article/jcj/64/12/64_12_937/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001098848
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed