Evaluation of Arteriolar Hyalinosis of the Skin of Patients With Chronic Congestive Heart Failure.

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  • Kishimoto Chiharu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Shioji Keisuke
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Ito Haruyasu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Kinoshita Makoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Lee Jong-Dae
    The First Department of Internal Medicine, Fukui Medical School
  • Shimizu Hiromasa
    The First Department of Internal Medicine, Fukui Medical School
  • Ueda Takanori
    The First Department of Internal Medicine, Fukui Medical School

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Abstract

To investigate whether microvascular lesions are present in the skin of patients with chronic congestive heart failure (CHF), skin biopsies were performed at the time of cardiac catheterization, and the results were compared with control subjects. The diagnosis of CHF was done by cardiac catheterization with reference to the elevation of plasma levels of brain natriuretic peptide (BNP). Although the severity of arteriolar hyalinosis did not correlate with the New York Heart Association functional class, increased hyalinosis was found in skin biopsies from 17 of 20 patients with CHF, but in none of the 6 control subjects. These results indicate that microangiopathic alterations in arterioles may exist in patients with CHF and therapy for peripheral vascular remodeling might be considered for such patients. (Circ J 2002; 66: 382 - 384)<br>

Journal

  • Circulation Journal

    Circulation Journal 66 (4), 382-384, 2002

    The Japanese Circulation Society

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