Acute Massive Pulmonary Thromboembolism Associated With Risperidone and Conventional Phenothiazines.
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- Kamijo Yoshito
- Departments of Emergency and Critical Care Medicine
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- Soma Kazui
- Departments of Emergency and Critical Care Medicine
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- Nagai Tomonori
- Legal Medicine, School of Medicine, Kitasato University, Sagamihara
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- Kurihara Katsuyoshi
- Legal Medicine, School of Medicine, Kitasato University, Sagamihara
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- Ohwada Takashi
- Departments of Emergency and Critical Care Medicine
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抄録
To assess the contribution of antipsychotic medication in Japanese patients suffering acute massive pulmonary thromboembolism, records of patients with idiopathic pulmonary thromboembolism associated with antipsychotic medication who were seen in a Japanese Emergency Center from January 1996 to December 2000 were reviewed. Age, gender, physical status, clinical presentation, antiphospholipid antibody, outcome, psychiatric profile, and antipsychotic medication use were examined. Seven patients had acute pulmonary thromboembolism associated with antipsychotic drug use, representing 44% of all patients with idiopathic pulmonary thromboembolism. The 7 patients developed symptoms in the early morning. More women than men were affected. In 5 cases, chlorpromazine and other phenothiazines had been prescribed, whereas in 2 cases, risperidone, a mixed serotonin 5HT2A and dopamine D2 receptor antagonist, had been taken for 40 days and 6 days, respectively. In 4 cases, including the patients taking risperidone, antiphospholipid antibodies were not present. Although statistically significant conclusions can not be drawn from this study, the data suggest that patients receiving risperidone, as well as conventional phenothiazines, are at risk for acute pulmonary thromboembolism, even if otherwise healthy. Strong affinity for the 5HT2A receptor of the novel antipsychotic may increase coagulability and the risk of thromboembolism. (Circ J 2003; 67: 46 - 48)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 67 (1), 46-48, 2003
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205104124800
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- NII論文ID
- 110002666207
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BD3sXlt1Slug%3D%3D
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- ISSN
- 13474820
- 13469843
- http://id.crossref.org/issn/13469843
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- PubMed
- 12520151
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可