17-Year Follow-up Study of a Patient With Obstructive Hypertrophic Cardiomyopathy With a Deletion Mutation in the Cardiac Myosin Binding Protein C Gene

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Author(s)

    • OGIMOTO Akiyoshi
    • The Second Department of Internal Medicine, Ehime University School of Medicine
    • HAMADA Mareomi
    • The Second Department of Internal Medicine, Ehime University School of Medicine
    • NAKURA Jun
    • Department of Geriatric Medicine, Ehime University School of Medicine
    • SHIGEMATSU Yuji
    • The Second Department of Internal Medicine, Ehime University School of Medicine
    • HARA Yuji
    • The Second Department of Internal Medicine, Ehime University School of Medicine
    • OHTSUKA Tomoaki
    • The Second Department of Internal Medicine, Ehime University School of Medicine
    • KIMURA Akinori
    • Medical Research Institute, Tokyo Medical and Dental University
    • MIKI Tetsuro
    • Department of Geriatric Medicine, Ehime University School of Medicine
    • HIWADA Kunio
    • The Second Department of Internal Medicine, Ehime University School of Medicine

Abstract

A 60-year-old Japanese man with obstructive hypertrophic cardiomyopathy was found to have a mutation in the cardiac myosin binding protein C gene: a single base deletion of a thymidine residue at nucleotide 11645 (codon 593) in exon 18. He was diagnosed at the age of 43 and has been followed for 17 years. During this follow-up period, echocardiograms and mechanocardiograms revealed progressive hypertrophy until the age of 54, then gradual dilation of the left ventricle associated with a decrease in the obstruction. Paroxysmal atrial fibrillation occurred at the age of 52 and progressed to chronic atrial fibrillation at the age of 53. He had congestive heart failure at the age of 58. (<i>Circ J</i> 2004; <b>68:</b> 174 - 177)<br>

Journal

  • Circulation Journal

    Circulation Journal 68(2), 174-177, 2004-01-20

    Japanese Circulation Society

References:  18

Cited by:  4

Codes

  • NII Article ID (NAID)
    110002667503
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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