Different Effects of Pravastatin and Cerivastatin on the Media of the Carotid Arteries as Assessed by Integrated Backscatter Ultrasound

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Author(s)

    • ITO Yoko
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • KAWASAKI Masanori
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • YOKOYAMA Haruko
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • OKUBO Munenori
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • SANO Keiji
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • ARAI Masazumi
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • NISHIGAKI Kazuhiko
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • UNO Yoshihiro
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • TAKEMURA Genzou
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • MINATOGUCHI Shinya
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University
    • FUJIWARA Hisayoshi
    • Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

Abstract

<b>Background</b> Currently, there are various types of statins used in the treatment of hyperlipidemia and coronary artery disease. The purpose of this study was to compare the effects of a lipophilic statin (cerivastatin) with those of a hydrophilic statin (pravastatin) on the carotid arterial media using integrated backscatter (IB) ultrasound. Cerivastatin (C) has a strong anti-proliferative effect (APE) on smooth muscle cells (SMCs), whereas pravastatin (P) has a weak effect. <b>Methods and Results</b> The IB values in the media of 72 segments of carotid arteries were measured in 36 patients with hyperlipidemia before and after statin therapy or diet for 6 months (C, n=13: P, n=12: diet, n=11). In addition, IB values of 34 segments of carotid arteries were measured in 34 patients without coronary risk factors. Intima - media thickness (IMT) and arterial stiffness (stiffness β) were measured by conventional echo at the same time. IB values did not significantly change in the P group (12.8±3.5 vs 12.7±2.7 dB), but decreased in the C group (12.1 ±2.9 vs 10.0±2.7 dB, p<0.01). Also, stiffness β did not significantly change in the P group (8.3±3.1 vs 7.6±2.5), but decreased in the C group (10.1±4.3 vs 7.9±3.3, p<0.05). IB values correlated with age (r=0.70, p<0.01) and stiffness β (r=0.67, p<0.01) in the 34 patients without coronary risk factors. <b>Conclusions</b> Statin therapy with cerivastatin, but not pravastatin, decreased the IB values of the carotid media and arterial stiffness. The difference between these 2 statins may be related to their effective dose range. (<i>Circ J</i> 2004; <b>68:</b> 784 - 790)<br>

Journal

  • Circulation Journal

    Circulation Journal 68(8), 784-790, 2004-07-20

    Japanese Circulation Society

References:  23

Cited by:  1

Codes

  • NII Article ID (NAID)
    110002667580
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
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