Different Effects of Pravastatin and Cerivastatin on the Media of the Carotid Arteries as Assessed by Integrated Backscatter Ultrasound

• Ito Yoko

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Kawasaki Masanori

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Yokoyama Haruko

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Okubo Munenori

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Sano Keiji

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Arai Masazumi

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Nishigaki Kazuhiko

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Uno Yoshihiro

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Takemura Genzou

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Minatoguchi Shinya

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

• Fujiwara Hisayoshi

  Regeneration & Advanced Medical Science, Graduate School of Medicine, Gifu University

抄録

Background Currently, there are various types of statins used in the treatment of hyperlipidemia and coronary artery disease. The purpose of this study was to compare the effects of a lipophilic statin (cerivastatin) with those of a hydrophilic statin (pravastatin) on the carotid arterial media using integrated backscatter (IB) ultrasound. Cerivastatin (C) has a strong anti-proliferative effect (APE) on smooth muscle cells (SMCs), whereas pravastatin (P) has a weak effect. Methods and Results The IB values in the media of 72 segments of carotid arteries were measured in 36 patients with hyperlipidemia before and after statin therapy or diet for 6 months (C, n=13: P, n=12: diet, n=11). In addition, IB values of 34 segments of carotid arteries were measured in 34 patients without coronary risk factors. Intima - media thickness (IMT) and arterial stiffness (stiffness β) were measured by conventional echo at the same time. IB values did not significantly change in the P group (12.8±3.5 vs 12.7±2.7 dB), but decreased in the C group (12.1 ±2.9 vs 10.0±2.7 dB, p<0.01). Also, stiffness β did not significantly change in the P group (8.3±3.1 vs 7.6±2.5), but decreased in the C group (10.1±4.3 vs 7.9±3.3, p<0.05). IB values correlated with age (r=0.70, p<0.01) and stiffness β (r=0.67, p<0.01) in the 34 patients without coronary risk factors. Conclusions Statin therapy with cerivastatin, but not pravastatin, decreased the IB values of the carotid media and arterial stiffness. The difference between these 2 statins may be related to their effective dose range. (Circ J 2004; 68: 784 - 790)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 68 (8), 784-790, 2004

  一般社団法人 日本循環器学会

キーワード

• Arteriosclerosis
• Integrated backscatter
• Statin
• Ultrasound

詳細情報

• CRID: 1390001205104579328
• NII論文ID: 110002667580
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.68.784
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 15277739
• Web Site: http://www.jstage.jst.go.jp/article/circj/68/8/68_8_784/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006278131
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可