Structure–Depolarizing Activity Relationship for Achatin-I, a Tetrapeptide with a<scp>d</scp>-Phe Residue, and Its Derivatives toward the Crayfish Giant Axon
書誌事項
- タイトル別名
-
- Structure-Depolarizing Activity Relationship for Achatin-I, a Tetrapeptide with a D-Phe Residue, and Its Derivatives toward the Crayfish Giant Axon.
この論文をさがす
抄録
Achatin-I (Gly-D-Phe-Ala-Asp) is a tetrapeptide isolated from the ganglia of an African giant snail (Achatina fulica Firussac). The compound and its derivatives were synthesized, and their effects on the action potential of the crayfish giant axon elicited by electrical stimulation were examined by an intracellular recording method. The membrane potential after the action potential had fallen was elevated by some compounds at an acidic but not neutral pH level. An analysis of the structure-activity relationship for the activity to elevate the afterpotential at an acidic pH level, suggests that the factors favorable for activity were the β-turn conformation, a β- or γ-carboxyl group in the C-terminal residue, appropriate hydrophobicity and/or bulkiness in the protecting groups for the α-amino group at the N-terminus, and the number of negative charges in the entire molecule.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 58 (6), 1123-1127, 1994
公益社団法人 日本農芸化学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206473641344
-
- NII論文ID
- 110002677028
-
- NII書誌ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- PubMed
- 7765350
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可