Formation of the Lignan (+)-Secoisolariciresinol by Cell-free Extracts of<i>Arctium lappa</i>

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  • Formation of the Lignan (+)-Secoisolariciresinol by Cell-free Extracts of Arctium lappa.

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Cell-free extracts of petioles of Arctium lappa catalyzed enantioselective formation of (+)-secoisolariciresinol [about 20% enantiomer excess (e.e.)] from achiral coniferyl alcohol in the presence of NADPH and H2O2. This is the first report of an enzymatic reaction to afford (+)-secoisolariciresinol enantioselectively.

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