In Vitro Survey of α-Glucosidase Inhibitory Food Components

• MATSUI Toshiro

• YOSHIMOTO Chiho

• OSAJIMA Katsuhiro

• OKI Tomoyuki

• OSAJIMA Yutaka

書誌事項

タイトル別名

• Inhibitation of Intestinal Glucose Absorption by Food Components. Part I. In Vitro Survey of .ALPHA.-Glucosidase Inhibitory Food Components.
• In Vitro Survey of アルファーGlucosidase Inh
• <i>In Vitro</i>Survey of<i>α</i>-Glucosidase Inhibitory Food Components

抄録

A survey of food components with α-glucosidase (AGH) inhibitory activity was conducted to identify a prophylactic effect for diabetes in food. Sardine muscle hydrolyzed by alkaline protease showed potent activity (IC₅₀=48.7 mg/ml) as well as green and oolong teas (IC₅₀=11.1 and 11.3 mg/ml, respectively). Furthermore, hydrolyzates prepared by various proteases gave differing AGH inhibitory activity. DEAE-Sephadex chromatography of the alkaline protease hydrolyzate eluted potent AGH inhibitors (IC₅₀=15.6 mg/ml) with a 50 mM phosphate buffer (pH 7.0) containing 0.3 M NaCl, and their subsequent separation by HPLC in an ODS column showed that there were some inhibitors possessing primary amino groups. This indicates that they would have been high anionic and peptidic compounds.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 60 (12), 2019-2022, 1996

  公益社団法人 日本農芸化学会

キーワード

• α-glucosidase inhibition
• diabetes
• physiologically functional food

詳細情報

• CRID: 1390001206476099200
• NII論文ID: 110002678424
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.60.2019
• COI: 1:CAS:528:DyaK2sXis1Krtg%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• ISSN: http://id.crossref.org/issn/09168451
• NDL書誌ID: 4109626
• PubMed: 8988634
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4109626
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.60.2019
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可