Inhibition of Tumor Necrosis Factor-α Production by Orally Administering a Perilla Leaf Extract
書誌事項
- タイトル別名
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- Inhibition of Tumor Necrosis Factor-.ALPHA. Production by Orally Administering a Perilla Leaf Extract.
- Inhibition of Tumor Necrosis Factor-アルフ
- Inhibition of Tumor Necrosis Factor-<i>α</i>Production by Orally Administering a Perilla Leaf Extract
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抄録
The overproduction of tumor necrosis factor-α(TNF-α) was suppressed by orally administering a perilla leaf extract (PLE). When mice were successively injected with OK-432, severe TNF-α was induced in the serum, but this elevated TNF-α level was reduced after an oral administration of PLE (400 μl/mouse). Oral administration of PLE also inhibited TNF-α production that was induced by muramyl dipeptide (500 μg/mouse) and OK-432 (3 KE/mouse). These characteristics were obtained from all strains of perilla. The inhibitory activity against TNF-α production was heat-stable, and the existence of several active molecules was suggested. When PLE was passed through an ultrafilter, the inhibitory activity against TNF-α production was collected in those fractions with a mass of 0.5 to 1 kDa and more than 10 kDa. When PLE was solvent-extracted, the strongest activity was recognized with aqueous preparation, although significant activity was also detected in preparations extracted with n-hexane and ethyl acetate. These findings suggest that the daily use of certain functional foods may be useful for controlling the host defense system.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 61 (8), 1292-1295, 1997
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681447442048
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- NII論文ID
- 110002678698
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DyaK2sXlvFeqtLc%3D
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- ISSN
- 13476947
- 09168451
- http://id.crossref.org/issn/09168451
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- NDL書誌ID
- 4287842
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- PubMed
- 9301110
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可