Superoxide Dismutase Inhibition of Oxidation of Ubiquinol and Concomitant Formation of Hydrogen Peroxide.

• NAKAYAMA Tsutomu

• HASHIMOTO Miku

• HASHIMOTO Kei

書誌事項

タイトル別名

• Superoxide Dismutase Inhibition of Oxid

抄録

We measured ubiquinone (CoQ₀) and hydrogen peroxide (H₂O₂) formed in the process of oxidation of ubiquinol (CoQ₀H₂). We found that copper-zinc superoxide dismutase and manganese superoxide dismutase inhibited both the CoQ₀ formation and the H₂O₂ formation only in the presence of chelators such as DTPA (diethylenetriaminepentaacetic acid). The amount of H₂O₂ was almost equal to that of CoQ₀, indicating that the H₂O₂ formation was coupled with the CoQ₀ formation. The lack of inhibitory effects of the corresponding heat-inactivated superoxide dismutase (SOD) confirmed that the inhibition by the original SOD was due to its enzymatic activity. We propose that CoQ₀H₂ oxidation occurs as a chain reaction with superoxide as the chain carrier and that SOD inhibits this reaction by lowering the superoxide concentration.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 61 (12), 2034-2038, 1997

  公益社団法人 日本農芸化学会

キーワード

• superoxide dismutase (SOD)
• superoxide
• hydrogen peroxide
• ubiquinol
• ubiquinone

詳細情報

• CRID: 1390282681450244480
• NII論文ID: 110002678874
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.61.2034
• COI: 1:CAS:528:DyaK1cXltFSmsw%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• ISSN: http://id.crossref.org/issn/09168451
• NDL書誌ID: 4406185
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4406185
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.61.2034
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可