Nystatin Effects on Vacuolar Function in<i>Saccharomyces cerevisiae</i>
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- BHUIYAN M. Shah Alam
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
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- ITO Yuji
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
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- NAKAMURA Atsuko
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
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- TANAKA Naotaka
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
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- FUJITA Kiyotaka
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
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- FUKUI Hiroshi
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
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- TAKEGAWA Kaoru
- Department of Life Sciences, Faculty of Agriculture, Kagawa University
書誌事項
- タイトル別名
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- Nystatin Effects on Vacuolar Function in Saccharomyces cerevisiae.
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抄録
The effects of nystatin, a polyene antibiotic, was studied in Saccharomyces cerevisiae by isolating and characterizing nystatin-sensitive mutants. We isolated a number of nystatin-sensitive mutants by ethylmethane sulfonate mutagenesis. One of these mutants, the nss1 mutant, was characterized in detail. The mutant was sensitive to stresses such as high temperature or high concentrations of monovalent and divalent cations. The nss1 mutants showed severe vacuolar protein sorting and vacuolar morphology defects. The nss1 mutant was demonstrated to have a mutational lesion in the known VPS16 gene, which is essential for vacuolar protein sorting in S. cerevisiae. All of the vacuolar deficient mutants (vps11, vps16, vps18, and vps33) were sensitive to nystatin. Nystatin was found to cause extensive enlargement of the vacuole in wild-type S. cerevisiae cells. These results are discussed with special reference to the vacuolar function of S. cerevisiae.<br>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 63 (6), 1075-1082, 1999
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206475991168
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- NII論文ID
- 110002679620
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DyaK1Mzls1Ojsw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 4787117
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- PubMed
- 10427694
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可