Association of White Blood Cell Count and Clustered Components of Metabolic Syndrome in Japanese Men

• Nagasawa Nobue

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine Department of Food and Nutrition, Faculty of Human Life, Jumonji University

• Tamakoshi Koji

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Yatsuya Hiroshi

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Hori Yoko

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Ishikawa Miyuki

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Murata Chiyoe

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Zhang Huiming

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Wada Keiko

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Otsuka Rei

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Mabuchi Tomoko

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

• Kondo Takaaki

  Department of Medical Technology, Nagoya University School of Health Science

• Toyoshima Hideaki

  Department of Public Health/Health Information Dynamics, Field of Social Life Science, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine

Abstract

Background The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated. Methods and Results A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) ≥25 kg/m²]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not. Conclusions The cluster of MS components based on insulin resistance may cause low-grade inflammation. (Circ J 2004; 68: 892 - 897)<br>

Journal

• Circulation Journal

  Circulation Journal 68 (10), 892-897, 2004

  The Japanese Circulation Society

Keywords

• Cardiovascular disease risk factor
• Japanese men
• Low-grade inflammation
• Metabolic syndrome
• White blood cell

Details

• CRID: 1390282680082133632
• NII Article ID: 110002692132
• NII Book ID: AA11591968
• DOI: 10.1253/circj.68.892
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 15459460
• Web Site: http://www.jstage.jst.go.jp/article/circj/68/10/68_10_892/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006292590
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed