Inhibition by Theanine of Binding of [<sup>3</sup>H]AMPA, [<sup>3</sup>H]Kainate, and [<sup>3</sup>H]MDL 105,519 to Glutamate Receptors
-
- KAKUDA Takami
- <i>Central Research Institute, Itoen Ltd.</i>
-
- NOZAWA Ayumu
- <i>Central Research Institute, Itoen Ltd.</i>
-
- SUGIMOTO Akio
- <i>Central Research Institute, Itoen Ltd.</i>
-
- NIINO Hitoshi
- <i>Central Research Institute, Itoen Ltd.</i>
書誌事項
- タイトル別名
-
- Inhibition by Theanine of Binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to Glutamate Receptors.
この論文をさがす
抄録
In an investigation of the mechanisms of the neuroprotective effects of theanine (γ-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [3H](RS)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, and [3H](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat cortical neurons. Theanine bound the three receptors, but its IC50 of theanine was 80- to 30,000-fold less than that of L-glutamic acid.<br>
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 66 (12), 2683-2686, 2002
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206474182784
-
- NII論文ID
- 110002693619
-
- NII書誌ID
- AA10824164
-
- COI
- 1:CAS:528:DC%2BD3sXht1KjtQ%3D%3D
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 6398727
-
- PubMed
- 12596867
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可