Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice.

• HASHIMOTO Takashi

  <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i>

• NONAKA Yuji

  <i>Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University</i>

• MINATO Ken-ichiro

  <i>Miyagi Agricultural College</i>

• KAWAKAMI Sachiko

  <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i> <i>Tottori Mycological Institute</i>

• MIZUNO Masashi

  <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i>

• FUKUDA Itsuko

  <i>Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University</i>

• KANAZAWA Kazuki

  <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i>

• ASHIDA Hitoshi

  <i>Division of Life Science, Graduate School of Science and Technology, Kobe University</i> <i>Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University</i>

Bibliographic Information

Other Title

• Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms,<i>Lentinus edodes</i>and<i>Agaricus blazei</i>, on the Expression of Cytochrome P450s in Mice

Abstract

  To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.<br>

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 66 (7), 1610-1614, 2002

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• lentinan
• <i>Lentinas edodes</i>
• <i>Agaricus blazei</i> polysaccharides
• cytochrome P450
• tumor necrosis factor-α (TNF-α)

Details

• CRID: 1390282681449965312
• NII Article ID: 110002693874
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.66.1610
• COI: 1:CAS:528:DC%2BD38XlvFemtr0%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 6254446
• PubMed: 12224654
• Web Site: http://id.ndl.go.jp/bib/6254446
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6254446
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.66.1610
• Web Site: https://search.jamas.or.jp/link/ui/2003032350
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed