Cytokine Production by the Murine Macrophage Cell Line J774.1 after Exposure to Lactobacilli

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  • MORITA Hirotsugu
    <i>Technical Research Laboratory, Takanashi Milk Products Co., Ltd.</i>
  • HE Fang
    <i>Technical Research Laboratory, Takanashi Milk Products Co., Ltd.</i>
  • FUSE Tetsuo
    <i>Technical Research Laboratory, Takanashi Milk Products Co., Ltd.</i>
  • OUWEHAND Arthur C.
    <i>Departments of Biochemistry and Food Chemistry, University of Turku</i>
  • HASHIMOTO Hideo
    <i>Technical Research Laboratory, Takanashi Milk Products Co., Ltd.</i>
  • HOSODA Masataka
    <i>Technical Research Laboratory, Takanashi Milk Products Co., Ltd.</i>
  • MIZUMACHI Koko
    <i>National Institutes of Livestock and Grassland Science</i>
  • KURISAKI Jun-Ichi
    <i>National Institute of Agrobiological Sciences</i>

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  Eleven strains of lactobacilli were tested for their ability to induce the murine macrophage-like cell line J774.1 to secrete cytokines. Some of the bacteria tested induce the production of interleukin(IL) 6, IL-12, and tumor necrosis factor α (TNF-α) by J774.1 cells. Seven strains also induced the production of IL-10. However, no IL-1β was produced. Lactobacillus acidophilus TMC 0356 significantly induced the production of more IL-6, IL-10, IL-12, and TNF-α than the other bacteria tested (p<0.0001; ANOVA). These results suggest that lactobacilli can activate macrophages to secrete both inflammatory and anti-inflammatory cytokines. Selected strains might be used to bring about pro or antiinflammatory immune reactions.<br>

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