Induction of Anti-inflammatory Responses by Dietary Momordica charantia L. (Bitter Gourd)

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Author(s)

    • Manabe Mariko MANABE Mariko
    • Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
    • Takenaka Ryo TAKENAKA Ryo
    • Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
    • OKINAKA Osamu
    • Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts

Abstract

  We assessed the immunomodulatory activity of <i>Momordica charantia</i> L. (bitter gourd), a vegetable that has been reported to possess various bioactivities. We examined the effect of bitter gourd on intestinal immunity by monitoring the TGF-β and IL-7 secretion from Caco-2 cells and the IL-10 and IL-12 secretion from THP-1 cells that are used as <i>in vitro</i> models of the intestinal epithelium and monocyte/macrophages, respectively. We also determined the <i>in vivo</i> immunological responses of rats fed on bitter gourd for 3 weeks. We found that bitter gourd induced a decrease in the intestinal secretion of IL-7 and an increase in the secretions of TGF-β and IL-10, these effects reflecting the bitter gourd-induced changes in systemic immunity, i.e., a decrease in the number of lymphocytes, increases in the populations of Th cells and NK cells, and increase in the Ig production of lymphocytes. Dietary bitter gourd may therefore induce both intestinal and also systemic anti-inflammatory responses.<br>

Journal

  • Bioscience, Biotechnology, and Biochemistry

    Bioscience, Biotechnology, and Biochemistry 67(12), 2512-2517, 2003-12-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  26

Cited by:  4

Codes

  • NII Article ID (NAID)
    110002694014
  • NII NACSIS-CAT ID (NCID)
    AA10824164
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09168451
  • NDL Article ID
    6794952
  • NDL Source Classification
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-G223
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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