Cloning and Characterization of a Caenorhabditis elegans cDNA Encodig a New Insulin/IGF-Like Peptide

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  • KAWANO Tsuyoshi
    <i>Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University</i>
  • TAKUWA Kyoko
    <i>Suntory Institute for Bioorganic Research</i>
  • ISHIGURO Masaji
    <i>Suntory Institute for Bioorganic Research</i>
  • NAKAJIMA Terumi
    <i>Suntory Institute for Bioorganic Research</i>
  • KIMURA Yasuo
    <i>Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University</i>

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タイトル別名
  • Cloning and Characterization of a Caenorhabditis elegans cDNA Encoding a New Insulin/IGF-Like Peptide
  • Cloning and Characterization of a<i>Caenorhabditis elegans</i>cDNA Encoding a New Insulin/IGF-Like Peptide

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  A Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide was cloned and examined. The predicted peptide shows significant sequence similarity with the peptide Ceinsulin-1 reported previously and contains a characteristic insertion consisting of three residues in the putative B domain as with the Ceinsulin-1. The gene expression pattern during development is almost identical to that of Ceinsulin-1. The predicted tertiary structure of the peptide is quite similar to that of Ceinsulin-1, and their predicted receptor-recognition surfaces also closely match. These facts suggest that both peptides could recognize the same receptor.<br>

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