Effect of α-Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very-low-density Lipoprotein

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  • ARAI Hirofumi
    <i>Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine</i>
  • UCHIDA Koji
    <i>Laboratory of Food and Biodynamics, Nagoya University School of Agricultural Science</i>
  • FUKUNAGA Kenji
    <i>Department of Public Health, Kansai Medical University</i>
  • NAGASAKA Yuji
    <i>Department of Nutrition, Yamaguchi Prefectural University</i>
  • MOHRI Satoshi
    <i>Industrial Technology Institute, Miyagi Prefectural Government</i>
  • FURUMOTO Hiroko
    <i>Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine</i>
  • KURAMITSU Yasuhiro
    <i>Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine</i>
  • NAKAMURA Kazuyuki
    <i>Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine</i>

書誌事項

タイトル別名
  • Effect of .ALPHA.-Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very-low-density Lipoprotein.
  • Effect of アルファ Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very low density Lipoprotein

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  The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with α-tocopherol (α-Toc; 170 μM). α-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that α-Toc protected apoE in VLDL from oxidative stress.<br>

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