Anti-angiogenic Activity of Tocotrienol

  • INOKUCHI Hitoshi
    <i>Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University</i>
  • HIROKANE Hisako
    <i>Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University</i>
  • TSUZUKI Tsuyoshi
    <i>Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University</i>
  • NAKAGAWA Kiyotaka
    <i>Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University</i>
  • IGARASHI Miki
    <i>Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University</i> Present address: <i>Sugiyama Human Nutrition Research Center, Sugiyama Jogakuen University</i>
  • MIYAZAWA Teruo
    <i>Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohoku University</i>

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  The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.<br>

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