Long-Term Beneficial Effect of Infarct-Related Artery Patency in Acute Anterior Myocardial Infarction in Patients With Poor Myocardial Viability in the Region-at-Risk

Access this Article

Search this Article

Author(s)

    • FUKUDA Daiju
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • YOSHIYAMA Minoru
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • SHIMADA Kenei
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • EHARA Shoichi
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • NAKAMURA Yasuhiro
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • AKIOKA Kaname
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • TAKEUCHI Kazuhide
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School
    • YOSHIKAWA Junichi
    • Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School

Abstract

<b>Background</b> Several studies have demonstrated the benefit of the patency of infarct-related artery (IRA) in acute myocardial infarction (AMI). However those studies have not been concerned with myocardial viability in the region-at-risk. In the present study the effect of the patency of IRA was investigated in the setting of anterior AMI with poor viable myocardium in the risk region. <b>Methods and Results</b> From 1993 to 1996 patients with a first time anterior AMI and poor viable myocardium in the region-at-risk at 1 month after onset were identified and enrolled. Patients with a totally occluded IRA were included in the Non-Open group (n=44), and patients with a reperfused IRA were included in the Open group (n=49). At 5 years after onset, left ventricular function was better preserved in the Open group than in the Non-Open group (p<0.05). Kaplan-Meier survival curves for cardiac mortality and event-free survival curves revealed poor prognoses in the Non-Open group over a 5-year period (p<0.05, respectively). The advantages of a patent IRA were further seen in health-related quality-of-life outcomes (p<0.05). <b>Conclusions</b> Even in patients with poor myocardial viability after an anterior AMI, the patency of the IRA is strongly associated with improved long-term survival, independent of residual myocardium viability. (<i>Circ J</i> 2004; <b>68:</b> 1110 -1116)<br>

Journal

  • Circulation Journal

    Circulation Journal 68(12), 1110-1116, 2004-11-20

    Japanese Circulation Society

References:  34

Cited by:  1

Codes

  • NII Article ID (NAID)
    110002695999
  • NII NACSIS-CAT ID (NCID)
    AA11591968
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13469843
  • Data Source
    CJP  CJPref  NII-ELS  J-STAGE 
Page Top