Detection of Amiodarone-Induced Pulmonary Toxicity in Supine and Prone Positions-High-Resolution Computed Tomography Study-

• Oyama Noriko

  Departments of Radiology, Hokkaido University Graduate School of Medicine

• Oyama Naotsugu

  Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Yokoshiki Hisashi

  Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Kamishima Tamotsu

  Departments of Radiology, Hokkaido University Graduate School of Medicine

• Nambu Toshikazu

  Departments of Radiology, Hokkaido University Graduate School of Medicine

• Tsutsui Hiroyuki

  Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Miyasaka Kazuo

  Departments of Radiology, Hokkaido University Graduate School of Medicine

書誌事項

タイトル別名

• High-Resolution Computed Tomography Study

抄録

Background The aim of the present study was to describe the effectiveness and feasibility of high-resolution computed tomography (HRCT) in patients in supine and prone positions to detect amiodarone-induced pulmonary toxicity (APT). With regard to the possible differential diagnosis, our second goal was to emphasize the clinical value of HRCT with the patients in supine and prone positions compared with other paraclinical tests. Methods and Results Thoracic HRCT taken in both positions for 23 patients who were administrated amiodarone were prospectively evaluated in the current study. High-resolution computed tomography scans obtained with the patient in a prone position were helpful in differentiating dependent opacity from lung disease in 11 out of 23 patients. In another 4 patients, HRCT scans obtained with the patient in a prone position were useful in confirming the presence of subtle ground-glass opacities, considered as APT. Combination of HRCT in supine and prone positions provided a more reproducible method for evaluating the global extent of APT than other paraclinical tests. Conclusions High-resolution computed tomography used in prone positions as well as a supine position could be an effective technique for reducing false-positive results in detection of APT and preventing the clinically serious pulmonary adverse effects by amiodanone. (Circ J 2005; 69: 466 - 470)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 69 (4), 466-470, 2005

  一般社団法人 日本循環器学会

キーワード

• Amiodarone
• High-resolution computed tomography
• Prone position
• Pulmonary toxicity
• Supine position

詳細情報

• CRID: 1390001205104749568
• NII論文ID: 110002696123
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.69.466
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 15791044
• Web Site: http://www.jstage.jst.go.jp/article/circj/69/4/69_4_466/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006262496
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可